Overview

The Comprehensive Addiction and Recovery Act (CARA) Community-based Coalition Enhancement Grants to Address Local Drug Crises Grants (CARA Local Drug Crises Grants) support community-based coalitions in preventing and reducing the use of opioids and methamphetamines and the misuse of prescription drugs among youth ages 12–18 throughout the United States. Administered by the Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC), in coordination with the Executive Office of the President, Office of National Drug Control Policy (ONDCP), and the Department of Health and Human Services (HHS), these grants serve as an enhancement to current or formerly funded Drug-Free Communities (DFC) Support Program recipients.

The program operates under the statutory authority of Section 103 of the Comprehensive Addiction and Recovery Act of 2016 (Pub. L. No. 114-198) and is funded through Assistance Listing 93.799. The CARA Support Program funds coalition activities within the United States and does not authorize funding for organizations or activities outside the United States.

Funding and Benefits

• Total Program Funding: $18,750,000
• Expected Number of Awards: 50
• Award Maximum: $75,000
• Cost Sharing or Matching Requirement: No
• Funding Instrument Type: Grant
• Opportunity Category: Discretionary
• Category of Funding Activity: Health

Eligibility

Eligible applicants are community-based coalitions addressing opioid, methamphetamine, and/or prescription drug use or misuse by local youth. Applicants must be current or former Drug-Free Communities (DFC) Support Program recipients. Eligible organizations include:

• Federally recognized Native American tribal governments
• County, city or township, and special district governments
• Private institutions of higher education, independent school districts, and public and state institutions of higher education
• Nonprofit organizations with or without 501(c)(3) status
• Other Native American tribal organizations
• State-recognized tribes and urban Indian organizations (as defined in Pub. L. No. 94-437)
• Professional associations, voluntary organizations, self-help groups, consumer and provider services-oriented constituency groups, community- and faith-based organizations, and tribal organizations

Applicants must document rates of misuse of opioids or use of methamphetamines that are higher than the national average over a sustained period. A CARA legal applicant (an organization applying on behalf of a coalition, the coalition, or the applicant coalition) must reside within the United States and/or U.S. territories.

Deadline and Timeline

• Closing Date: June 8, 2026 — electronically submitted applications must be submitted no later than 11:59 pm ET
• Posted Date: May 6, 2026
• Archive Date: July 8, 2026
• Funding Opportunity Number: CDC-RFA-CE-26-0110

Application Process

Applications must be submitted electronically through Grants.gov. Applicants should apply via the Grants.gov website to track application status and subscribe to updates.

Contact Information

• Grantor Contact: Christi Jones
• Email: CARA_NOFO@cdc.gov