The NIH Blueprint for neuroscience is seeking applications to pilot the establishment of an integrated resource for users to explore, analyze, and download processed deidentified human brain single-cell transcriptomics and epigenomics data.

This resource will generate a unified cell type taxonomy and provide users with a draft annotatable cell-type nomenclature and the ability to map community generated single cell omics data to the taxonomy.

This pilot will lay the groundwork for an expanded and sustained effort to increase utility and accessibility of human cell-type classification data across multiple NIH consortia.

Scope of Work

The award made via this pilot program will establish an integrated resource that allows users to explore, analyze, and download processed de-identified human brain single-cell transcriptomics and epigenomics data harmonized across reference and disease datasets.

The recipient will provide a federated one-stop hub to access underlying raw datasets.

The recipient will enlist the collaboration of at least three major existing data archives housing NIH generated datasets, ingest raw or processed data, harmonize datasets as needed, and develop a dashboard of online exploration and discovery tools.

Eligibility

All organizations administering an eligible parent award may apply for a supplement under this NOFO. This includes Higher Education Institutions, Nonprofits, For-Profit Organizations, Local Governments, State Governments, Federal Government, Foreign Organizations, and other eligible organizations.

Applicant organizations must complete and maintain the following registrations: System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code, Unique Entity Identifier (UEI), eRA Commons, and Grants.gov.

Budget and Duration

Annual direct costs may not exceed $1M and must reflect the actual needs of the proposed project.

The maximum project duration for this Pilot Project is 3 years.

Additional Information

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

The NIH will not accept duplicate or highly overlapping applications under review at the same time.

Key Dates

• Posted Date: October 11, 2024

• Open Date (Earliest Submission Date): January 14, 2025

• Letter of Intent Due Date(s): January 14, 2025

• Application Due Dates: February 14, 2025

• Expiration Date: February 15, 2025

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