Introduction

This Notice of Funding Opportunity (NOFO) invites applications for R61/R33 grants to investigate the impact of stressors on the biological mechanisms of aging. The research should focus on stress exposures during adulthood, examining how these stressors affect the hallmarks of aging, lifespan, healthspan, and resilience. The NOFO encourages the use of experimental model systems, including in vitro systems, laboratory animals, and well-characterized animal populations.

Scope of Work

The research should be divided into two phases: an exploratory phase (R61) and a developmental phase (R33). The R61 phase aims to identify stressors that impact the hallmarks of aging during adulthood. The R33 phase will then expand upon the findings from the R61 phase to investigate the effects of stressors on lifespan, healthspan, and resilience.

Eligibility

Eligible applicants include higher education institutions, nonprofits, for-profit organizations, local and state governments, federal agencies, and foreign organizations. Applicants must complete and maintain registrations in the System for Award Management (SAM), eRA Commons, and Grants.gov.

Budget and Duration

The maximum budget for the R61 phase is $500,000 over two years, with a maximum of $250,000 per year. The maximum budget for the R33 phase is $1,500,000 over three years, with a maximum of $500,000 per year. The total project period cannot exceed five years.

Additional Information

Applicants are encouraged to submit a letter of intent by the deadline. The NOFO provides detailed instructions for application submission, including specific requirements for the research plan, data management and sharing plan, and human subjects research.

Key Dates

• Posted Date: August 27, 2024
• Open Date: October 07, 2024
• Letter of Intent Due Date: October 7, 2024
• Application Due Date: November 08, 2024

Application Process

Applications must be submitted electronically through Grants.gov. Applicants must complete all required registrations before the application due date.

Selection Process

Applications will be evaluated for scientific and technical merit by a Scientific Review Group convened by NIA. Applications may undergo a selection process in which only those deemed to have the highest scientific merit will be discussed and assigned an overall impact score.

Contact Information

• Scientific/Research Contact: Jennifer Fox, Ph.D., National Institute on Aging (NIA), Telephone: 301-402-4816, Email: jennifer.fox@nih.gov
• Peer Review Contact: Ramesh Vemuri, Ph.D., National Institute on Aging (NIA), Telephone: 301-402-7700, Email: ramesh.vemuri@nih.gov
• Financial/Grants Management Contact: Mitchell Whitfield, National Institute on Aging (NIA), Telephone: 301-827-6373, Email: mitchell.whitfield@nih.gov

Reporting Requirements

Recipients will be required to submit an annual Research Performance Progress Report (RPPR) and financial statements. A final RPPR, invention statement, and expenditure data portion of the Federal Financial Report are required for closeout of an award.

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