The National Institute of Environmental Health Sciences (NIEHS) announces the Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional), identified as funding opportunity RFA-ES-27-004. This program supports problem-based, solution-oriented research Centers that consist of multiple, integrated projects representing both biomedical and environmental science and engineering disciplines, along with cores for administration, translational research, engagement, and research support.
The Superfund Research Program (SRP) Center grants support innovative research and training through multi-project, interdisciplinary grants. Authorized under the Superfund Amendments and Reauthorization Act of 1986 (SARA), these university-based Centers conduct research to address scientific uncertainties facing the national Superfund program. The goal of each SRP Center is to improve public health by supporting integrative, multidisciplinary research that is problem-based, solution-oriented, and relevant to Superfund priorities. Applicants are expected to design research Centers that integrate biomedical research (e.g., toxicology, epidemiology, mechanistic studies) with environmental science and engineering (e.g., remediation, geosciences, ecological sciences).
Per 42 USC 9660(a)(3), eligible applicants are limited to accredited institutes of higher education within the United States. Non-domestic (non-U.S.) entities, non-domestic components of U.S. organizations, and foreign components are not eligible to apply. Only one application per institution is allowed. Eligible applicants are encouraged to subcontract as appropriate with other organizations to conduct portions of the research, which may include generators of hazardous wastes, persons involved in detection and treatment of hazardous substances, facility owners and operators, and state or local governments. Applications will be peer-reviewed through standard NIH processes, and only meritorious applications will be considered for funding.
SRP Centers support research and training in the following areas, as authorized by SARA Section 311(a):
Centers are expected to assemble interdisciplinary research teams with expertise in both biomedical research and environmental science and engineering to advance scientific knowledge using innovative and integrated approaches.
No late applications will be accepted. Applicants are encouraged to apply early to allow adequate time to correct any errors found during the submission process.
Applicants must follow the Multi-Project (M) Instructions in the NIH How to Apply Application Guide, except where program-specific instructions deviate. Applications may be submitted through the NIH ASSIST system or through an institutional system-to-system (S2S) solution to Grants.gov and eRA Commons. Conformance to all requirements is strictly enforced; applications that do not comply may be delayed or not accepted for review.
National Institutes of Health
National Institute of Environmental Health Sciences
Hazardous Substances Research Branch
Email: NOFO.Information@niehs.nih.gov
Phone: 301-402-2541
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Submission Deadline
Sep 25, 2028
Review Period
Mar 1, 2027
Award Announcement
May 1, 2027
Project Start
Jul 1, 2027
Collaboration
Multi-institutional
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