This funding opportunity, RFA-AG-26-001, focuses on the National Longitudinal Study of Adolescent to Adult (Add) Health Wave VII. It aims to leverage the existing Add Health cohort to understand risk and resilience factors for Alzheimer's disease and related dementias (AD/ADRD) at midlife. This initiative is sponsored by the National Institutes of Health (NIH) and falls under the Department of Health and Human Services.

Key Objectives and Focus

The primary goal of this cooperative agreement is to continue and enhance the Add Health study. This includes conducting mixed-mode surveys, in-home health visits, and venous blood collections. The study also focuses on data dissemination activities to make the resource accessible to researchers.

A significant emphasis is placed on developing Add Health as a population-representative data resource. This resource will be used to understand how life course factors shape inequities in outcomes related to aging and AD/ADRD. The study aims to provide valuable insights into the factors influencing the development of these conditions.

The research will assess risk and resilience for Alzheimers disease and related dementias (AD/ADRD). This is a uniquely valuable timepoint, as Add Health respondents are now at midlife. The study will explore the long-term effects of adolescent experiences on later-life health outcomes.

Funding Details and Award Information

This is a single-source funding opportunity. The funding instrument type is a cooperative agreement. There is no cost sharing or matching requirement for this grant.

The estimated total program funding and award ceiling/floor are not specified in this announcement. The expected number of awards is also not provided. Applicants should refer to the full announcement for potential updates.

The funding falls under Assistance Listings 93.279 (Drug Use and Addiction Research Programs), 93.865 (Child Health and Human Development Extramural Research), and 93.866 (Aging Research). These listings highlight the breadth of research areas supported by this opportunity.

Eligibility Criteria

Eligible applicants include public and state-controlled institutions of higher education.

• Non-domestic (non-U.S.) entities are not eligible to apply.

• Non-domestic components of U.S. organizations are also ineligible.

• Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Applicants must ensure they meet all eligibility requirements before submitting their application. Failure to comply with these requirements may result in disqualification.

Application and Submission Information

The original and current closing date for applications is October 17, 2025. The archive date is November 22, 2025. Applicants should submit their applications well in advance of the deadline.

The Funding Opportunity Number is RFA-AG-26-001. This number should be referenced in all communications regarding this opportunity. The Funding Opportunity Title is Single Source: National Longitudinal Study of Adolescent to Adult (Add) Health Wave VII (U01 Clinical Trial Not Allowed).

For inquiries, contact NIH Grants Information at grantsinfo@nih.gov. Additional contacts may be listed in Section VII of the full opportunity announcement.