The Medical Research Council (MRC) offers the Developmental Pathway Funding Scheme to advance novel therapeutics, medical devices, diagnostics, and other interventions. This is stage two of the funding opportunity, and application is by invitation only.

Key Dates and Funding Details

The funding opportunity is currently open, with a closing date of July 2, 2025, at 4:00 PM UK time. The opening date was May 7, 2025, at 9:00 AM UK time. This is an ongoing funding opportunity with application rounds closing every March, July, and November.

The total fund available is £30,000,000. There is no limit to the amount you can apply for, but the requested funding should align with the project's needs. The MRC typically funds 80% of the project's full economic cost.

Funding decisions will be made between September 17-18, 2025, and applicants will be informed within 10 working days of the decision meeting.

Project Scope and Focus

Projects can span any stage of the developmental pathway. This includes early development, pre-clinical refinement and testing, and early-phase clinical studies and trials (up to phase 2a). The focus is on developing and testing novel interventions.

The scheme supports a wide range of projects aimed at improving healthcare. This includes therapeutics, medical devices, and diagnostics. The goal is to translate promising research into practical applications.

Applicants should demonstrate a clear pathway to impact. This includes a well-defined plan for development and testing. Projects should address significant unmet needs in healthcare.

Eligibility Criteria

To be eligible, applicants must be invited to apply for stage two of this funding opportunity. Ensure you meet all eligibility requirements before preparing your application.

While specific eligibility criteria are not detailed here, typical requirements often include:

• Being based at an eligible UK research organization.

• Holding a relevant academic or research position.

• Having a track record of successful research in the proposed area.

It is crucial to carefully review the full eligibility criteria. Contact the MRC for clarification if needed.

Application Process

As this is an invited stage, ensure you have received your invitation before starting the application process. The application must be submitted through the MRC's online system.

Prepare a detailed project proposal. This should include a clear description of the research plan, methodology, and expected outcomes. A well-structured proposal is essential for a successful application.

Pay close attention to the assessment criteria. Address each criterion thoroughly in your application. Seek feedback from colleagues to improve your proposal.

Assessment Criteria

Applications will be assessed based on several criteria. These include scientific merit, feasibility, and potential impact. The quality of the research team and the proposed methodology are also important.

The assessment process involves peer review by experts in the relevant field. Reviewers will evaluate the novelty and significance of the proposed research. They will also assess the potential for translation into practical applications.

A funding decision meeting will be held to finalize the awards. The MRC aims to make funding decisions in a timely manner. Applicants will be informed of the outcome shortly after the meeting.