This Notice of Funding Opportunity (NOFO) aims to promote epidemiologic research investigating novel and innovative hypotheses on emerging risk factors associated with the development of liver cancer in the United States.

The funded projects will contribute to the body of evidence needed to inform evidence-based prevention and control strategies of liver cancer.

This NOFO utilizes the Research Exploratory/Developmental Research Grant (R21) mechanism and runs in parallel with a companion NOFO of identical scope, which utilizes the Research Project Grant (R01) mechanism.

Scope of Work

This NOFO seeks applications focusing on epidemiologic research investigating emerging and new etiologic factors and liver cancer risk in populations relevant to the United States.

Applications should include, when possible, relevant biospecimens to evaluate associated risk factors and liver cancer risk.

Applications that include an investigation on viral-associated liver cancer must provide strong rationale that outlines the added innovation or new knowledge to be gained from the current evidence of viral-associated liver cancer etiology.

Eligibility

Eligible organizations include Higher Education Institutions, Nonprofits, For-Profit Organizations, Local Governments, State Governments, Federal Government, U.S. Territory or Possession, and Other.

Foreign Organizations are also eligible to apply.

Applicant organizations must complete and maintain the following registrations: System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code, Unique Entity Identifier (UEI), eRA Commons, and Grants.gov.

Budget and Duration

The combined budget for direct costs for the two-year project period may not exceed $275,000.

No more than $200,000 may be requested in any single year.

The maximum project period is 2 years.

Additional Information

Applicant organizations may submit more than one application, provided that each application is scientifically distinct

. The NIH will not accept duplicate or highly overlapping applications under review at the same time.

Key Dates

• Posted Date: October 10, 2024

• Open Date (Earliest Submission Date): January 16, 2025

• Application Due Dates: February 16, 2025, March 16, 2025

• Expiration Date: May 08, 2025

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