This Notice of Funding Opportunity (NOFO) invites applications for the Clinical and Translational Science Award (CTSA) Program hubs. The CTSA Program aims to accelerate the translation of research discoveries into improved patient care by advancing clinical and translational science (CTS).

The program focuses on developing, demonstrating, and disseminating scientific and operational innovations that improve the efficiency and effectiveness of clinical translation. This NOFO is part of a required set of companion applications, including the Clinical and Translational Science Award (UM1) and companion Institutional Career Development Award (K12).

Scope of Work

The CTSA Program hubs will be part of a national, collaborative consortium focused on bringing more treatments to all people more quickly through advancing clinical and translational science (CTS). The program aims to develop, demonstrate, and disseminate scientific and operational innovations that improve the efficiency and effectiveness of clinical translation from identification to first-in-human studies to medical practice implementation to community health dissemination.

Eligibility

Eligible applicants include Higher Education Institutions, Nonprofits, For-Profit Organizations, Local Governments, State Governments, Federal Governments, and Other organizations. Organizations with active grants funded under NOFOs PAR-15-304, PAR-18-464, PAR-18-940 & PAR-21-293 that have more than 16 months of support remaining on the day of the submission deadline are not eligible to apply. NCATS encourages multiple institutions to participate in a single hub application, where this may further advance the goals of the program.

Budget and Duration

The amount of funding that applicants can request depends on the amount of NIH funding they receive. The maximum direct cost amount (DC) that may be requested for the UM1 budget is based on the sum of two NIH funding components: A) 5-year average of the most current NIH DC funding of the applicant institution, plus B) 5-year average of the most current NIH DC of any partner(s). The maximum project period is 7 years.

Additional Information

This NOFO only accepts applications that are part of a collaborative set of multiple applications. The set must contain 1 application to this UM1 NOFO and 1 application to the K12 NOFO; it may also contain 1 application to the T32 predoc NOFO, 1 application to T32 postdoc NOFO, 1 application to R25 NOFO, and/or up to 2 applications for the RC2 NOFO.

Key Dates

• Posted Date: September 04, 2024

• Open Date (Earliest Submission Date): January 13, 2025

• Letter of Intent Due Date(s): 30 days before the application due date

• Expiration Date: September 29, 2027

Application Process

• The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system-to-system solution.

• Applicants must follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide except where instructed in this notice of funding opportunity to do otherwise.

• Applications must be submitted electronically following the instructions described in the How to Apply - Application Guide. Paper applications will not be accepted.

Selection Process

• Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) convened by NCATS, in accordance with NIH peer review policy and procedures, using the stated review criteria.

• Applications may undergo a selection process in which only those applications deemed to have the highest scientific and technical merit (generally the top half of applications under review) will be discussed and assigned an overall impact score.

• Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications.

Contact Information

• eRA Service Desk: https://www.era.nih.gov/need-help (preferred method of contact), Telephone: 301-402-7469 or 866-504-9552 (Toll Free)

• General Grants Information: GrantsInfo@nih.gov (preferred method of contact), Telephone: 301-480-7075

• Grants.gov Customer Support: Contact Center Telephone: 800-518-4726, Email: support@grants.gov

• Scientific/Research Contact(s): Christopher M. Hartshorn, Ph.D., National Center for Advancing Translational Sciences (NCATS), Telephone: 301-402-0264, Email: CTSANOFOQuestions@mail.nih.gov

• Peer Review Contact(s): Victor Henriquez, Ph.D., National Center for Advancing Translational Sciences (NCATS), Telephone: 301-435-0813, Email: CTSANOFOQuestions@mail.nih.gov

• Financial/Grants Management Contact(s): Stacia Fleisher, National Center for Advancing Translational Sciences (NCATS), Telephone: 301-435-0851, Email: CTSANOFOQuestions@mail.nih.gov

Reporting Requirements

• When multiple years are involved, recipients will be required to submit the Research Performance Progress Report (RPPR) annually and financial statements as required in the NIH Grants Policy Statement Section 8.4.1 Reporting.

• A final RPPR, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Statement Section 8.6 Closeout.

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