The Office of Strategic Coordination (OSC), The Common Fund, aims to enhance the validity of impactful biomedical research.

This Notice of Special Interest (NOSI) provides administrative supplements to active NIH-funded awards to conduct preparatory activities for high-fidelity replication studies using independent contract research resources.

The initiative focuses on replicating impactful preclinical studies with potential for translation to clinical use, prioritizing those with high potential impact on public health.

Scope of Work

This NOSI supports preparatory activities to enable replication of impactful NIH-funded biomedical studies by an independent contract research organization (CRO). Applications must identify a preclinical study with high potential impact on public health that is amenable to replication by an independent CRO.

The study to be replicated can be an experimental study or a validation study and must be completed within the one-year budget period.

The applicant must be prepared to engage with the CRO immediately after the start of an award, providing required research methods, protocols, and unique experimental materials as soon as possible.

They must be available for consultation with the CRO throughout the award period to ensure high fidelity to the original study.

Eligibility

Applicants must be requesting administrative support to an active NIH-funded parent award.

The parent award must be able to receive funds at the time of the earliest start date and be active throughout the one-year project period.

The parent award may be in an extension period, but requests for no-cost extensions on the parent award to accommodate a supplement will not be permitted.

Small business activity codes are not eligible

. Applicants are encouraged to consult the program officer of the parent grant to confirm eligibility.

Budget and Duration

The supplement budget request must reflect the actual needs of the proposed one-year project and is limited to $50,000 direct cost per project.

Requests may be for one year of support only.

The parent award must be an active NIH award that is able to receive funds at the time of the earliest start date and be active throughout the one-year project period.

Additional Information

The methods and results of the replication studies conducted through this NOSI will not be made public without the consent of the principal investigator(s).

The Common Fund will provide funds directly to the CRO to conduct the replication study.

The Common Fund will only support replication/validation of preclinical research studies and will prioritize studies that have the potential for translation to clinical use. Human subjects studies will not be supported.

Key Dates

• Release Date: October 11, 2024

• First Available Due Date: November 15, 2024

• Expiration Date: November 22, 2024

For More funding Opportunities, Visit Global Funding Opportunities.